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Trazodone for sleep headaches are as effective paroxetine for PTSD, and both reduce patients' fatigue depression, according to a January 2014 study published in The Journal of Neurology, Neurosurgery, and Psychiatry. What's more, a 2013 study published in The American Journal of Psychiatry found that paroxetine, which is often used as an anti-anxiety medication, helps patients cope with traumatic memories, according to the BBC. That has led to a "paroxetine versus anti-anxiety drug war," according to a 2012 article in The Washington Post, which added that paroxetine was "the most commonly prescribed anti-depressant." A 2013 study published in The Lancet Psychiatry estimated that paroxetine's effectiveness was equal to that of diazepam, a common anti-anxiety drug for sleeplessness. Both drugs act similarily on the GABA receptors in brain. "The findings of the present studies suggest that effectiveness of SSRI in the treatment posttraumatic stress is similar to that of a class drugs called atypical antidepressants to treat insomnia, which are also effective for posttraumatic stress disorder," the authors claimed. For the study, researchers recruited 10 male and female military veterans. During one seven-week treatment study, the subjects used SSRIs, an SSRI and placebo, in addition to the benzodiazepine diazepam. In another study included the study, researchers compared SSRIs and escitalopram, another SSRIs. On average, SSRIs were 25% effective for treating post-traumatic stress disorder, the researchers noted. "These data suggest that compared with the drug alone, SSRIs are associated with statistically small but clinically meaningful improvements in PTSD severity across different symptom areas," wrote the authors of "Paroxetine Versus Prolonged-Release SSRI Treatment for Veterans With Chronic Posttraumatic Stress Disorder," according to a study published in Clinical Psychological Science 2013. Some of the benefits taking paroxetine and other SSRIs for a few weeks, rather than months or longer, have not been scientifically established, but the effectiveness of those drugs varies, according to a 2012 study published in the Canadian Journal of Psychiatry. Studies have also demonstrated that the drugs work differently for each patient, according to the Mayo Clinic. "The results of this clinical investigation suggest that the effects of repeated-suppressive oral SSRI treatments in PTSD patients may vary depending not only on the number of SSRI treatment days received, but also the characteristics and severity of PTSD patients' response to the SSRI," authors wrote. These preliminary findings suggest that using SSRIs has different effects by gender. After receiving SSRIs for ten weeks, men were slightly more compliant with treatment than women, the researchers wrote in 2009 study the Archives of General Psychiatry. Another 2009 study, which focused on SSRI use in the treatment of symptoms associated with acute stress disorder and the primary PTSD diagnosis, revealed no overall difference in adherence by gender. However men were 10% more likely to use paroxetine and 19% more likely to take escitalopram, the researchers noted. In 2014, the American Psychiatric Association updated its official guidelines on SSRI use, indicating that people can use paroxetine for up to six months, with only a few instances in which the drug was recommended for use an indefinite period. One month after receiving paroxetine, most veterans in the study reported that mental and physical symptoms improved somewhat, according to the report. After only one week of treatment, patients reported "significant improvement" in symptoms, such as sadness and insomnia. Paroxetine isn't the only antidepressant medication for treating sleep problems, however. It's also been a recommended treatment for depression but "at the dose needed," according to Dr. Frank Ochberg, of the Mayo Clinic, National Sleep Foundation and the Institute of Veterans Affairs. Paroxetine works quickly, so patients should take it generic drug regulations in canada as prescribed without any extra guidance, Ochberg said. "It's very unlikely that you will experience side effects," he told FoxNews.com. "It's not addictive. It'll do just fine, as long you're following the directions."
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